Drought is one the gravest aspect of the climate change in the present decade. This kind of climate change neither allow the farmers to prepare itself in advance nor it can escape the season once the sowing is completed. The impact is so widespread that it causes huge crop losses and poses serious threat to food security globally. Wheat being the third most staple crop around the world after rice and maize, has been severely affected by this climatic menace. Drought tolerance has become an important part of the today’s research and development of drought resilient lines in wheat is the current breeding trait of interest for plant breeders. Identification for novel genetic resources and associated genomic region clarifies the mechanisms behind drought tolerance and its regulation. The biochemical & physiological aspects associated with the said trait and their interface with the associated genomic regions, identified using genome wide associated studies (GWAS), provides deep insights for drought tolerance & its mechanism. Several significant genetic resources have been identified in the recent past which has proved their worth in development of drought tolerant lines in wheat. This review highlights the latest research and facts associated with several aspects of drought tolerance in wheat and provide profound solutions that are significant for the future wheat breeding programs.