Environment presents various kinds of stress to the growing plants and plays an important role in determining the productivity specially in case of food crops. Amongst these stresses, biotic stress is the one which has got prominent role in deciding the productivity of a crop in a season. Biotic stress poses a serious threat to the crop productivity which enhances the use of insecticide and pesticide on the crops. Millets provides an ideal gene pool for its resistance against various diseases caused from the pathogens. This makes them the first choice amongst the farmers for their plantations and cultivations at various altitudes in different seasons. This review comprehensively provides an insight into the disease resistance in millets and various mechanisms and aspects associated with it.