Biomanufacturing, a green production process that turns waste into services, is critical for long-term development and the expansion of the bioeconomy. It uses little chemicals and ingredients, making it eco-friendly. The high rate of climate change needs the substitution of environmentally harmful activity. Biomanufacturing advances have boosted bioprocess sustainability, scalability, and competency, preparing them for industrial usage. However, problems such as numerous ministries monitoring India's biomanufacturing industry, a weak private biotech financing climate, and a change in focus from basic to applied research can all result in lower-quality research. The BioE3 (Biotechnology for Economy, Environment and Employment) policy intends to promote high-efficiency biomanufacturing in India, with the goal of creating an independent, affluent, clean, and sustainable country. The policy promotes innovation, scale-up, and biomanufacturing of speciality chemicals, enzymes, biopolymers, smart proteins, veterinary products, precision biotherapeutics, and services. Modern technology has significant implications for industrial applications, particularly large-scale bioproduct manufacturing. For successful bioproduct manufacturing, bioprocesses must be upgraded from the laboratory to the industrial scale. This chapter discusses the BIOE3 policy and provides an overview of sustainable biomanufacturing, which includes a variety of sectors where biomanufacturing is being used for long-term growth, such as high-value bio-based chemicals, biopolymers, enzymes, small protein and functional foods, prevention bio thermotherapy, climate resilient agriculture, carbon capture and utilisation, marine and space research.